Drug Interactions: Reactions with Grapefruit and Related Citrus Fruits
Many people prefers to take medication with citrus fruit juice especially grape fruit juice because of delicious taste, but grape fruit juice interacts with medication, this is also common with citrus fruit juice. There are a number of factors that are responsible for drug interaction between citrus fruit juice and co administered medication. Citrus juices increase the absorption of some medicines by inhibiting CYP3A4 mediated metabolism or by inhibiting Pgp, this due to some components of citrus fruits. This review article contains the results of drug interaction of the drugs of different categories (antihistamines, cholesterol lowering drugs, psychiatric medications, calcium channel blockers, immunosuppressant drugs) with citrus fruit juice on the basis of clinical trials. And it is suggested to avoid grape fruit/citrus fruit juice at least for 72 hrs after administration of the drug otherwise it will be harmful for the body and may be life threatening.
Nisha. Fernandes and Swati. Jagdale. Superdisintegrants effect on three model drugs from different BCS classes, RJPT Research Journal of pharmacy and Technology 2:335-337 (2009).
N. Zhao and L.L Augsburger. Functionality Comparison of 3 Classes of Superdisintegrants in Promoting Aspirin Tablet Disintegration and Dissolution, AAPS PharmSciTech 6: 634-36 (2005).Page212
S.K Bhattu, M.A Repka, S. Majumdar and R.Y Madhusudan RY. Formulation and evaluation of rapidly disintegrating fenoverine tablets: Effect of superdisintegrants, Drug Development and Industrial Pharmacy 33: 1225-1232 (2007).
P. Martino, S. Martelli and P. Wehrle. Evaluation of different fast melting disintegrants by means of a central
composite design, Drug development and Industrial Pharmacy 1: 109-121(2005)
J.A Mulla and S.Fatima. Fast Dissolving Tablets of Promethazine: A Novel Oral Formulation for the treatment of Fractionated Radiotherapy Induced Nausea and Emesis, Indian Drugs 45: 314 - 317(2008).
C.M Setty, D.V Prasad and V.R Gupta. Development of fast dispersible aceclofenac tablets: Effect of functionality of superdisintegrants, Indian J Pharm Sci 70: 180–185(2008).
S. Chakraborty, M. Khandai, S.P. Singh. Comparative Study on the effect of natural and synthetic
superdisintegrants in the formulation of fast dissolving tablets, Indian Journal of Green Pharmacy 2: 22-25(2008).
I as author hereby declare that the submitted manuscript is my own original work and has not been submitted and published in any other journal.