Drug Interactions: Reactions with Grapefruit and Related Citrus Fruits

  • Arun Sharma NKBR college of pharmacy, Meerut
  • Keshari Keshore Jha NKBR College of Pharmacy and Research Center, Meerut- Hapur road phaphunda meerut-245206
  • Sachin Kumar NKBR College of Pharmacy and Research Center, Meerut- Hapur road phaphunda meerut-245206
  • Arun Kumar NKBR College of Pharmacy and Research Center, Meerut- Hapur road phaphunda meerut-245206
  • Parkhi Rastogi NKBR College of Pharmacy and Research Center, Meerut- Hapur road phaphunda meerut-245206
Keywords: citrus, fruit, juice, drug, interactions, grapefruit, immunosuppressants

Abstract

Many people prefers to take medication with citrus fruit juice especially grape fruit juice because of delicious taste, but grape fruit juice interacts with medication, this is also common with citrus fruit juice. There are a number of factors that are responsible for drug interaction between citrus fruit juice and co administered medication. Citrus juices increase the absorption of some medicines by inhibiting CYP3A4 mediated metabolism or by inhibiting Pgp, this due to some components of citrus fruits. This review article contains the results of drug interaction of the drugs of different categories (antihistamines, cholesterol lowering drugs, psychiatric medications, calcium channel blockers, immunosuppressant drugs) with citrus fruit juice on the basis of clinical trials. And it is suggested to avoid grape fruit/citrus fruit juice at least for 72 hrs after administration of the drug otherwise it will be harmful for the body and may be life threatening.

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Published
2009-01-15
How to Cite
Sharma, A., Jha, K. K., Kumar, S., Kumar, A., & Rastogi, P. (2009). Drug Interactions: Reactions with Grapefruit and Related Citrus Fruits. The Pharma Research, 1(01), 1-14. Retrieved from https://thepharmaresearch.info/ejournal/index.php/tphres/article/view/1
Section
Review